January 2002  National Bond Market Committee recommended the establishment of a national depository. 
September 2003 CSD Implementation Committe was formed.
May 2004 A contract was awarded to Millenium Information Technology (MIT) of Sri Lanka to implement a Turn-key Technology (MIT) for a depository and primary auction systems.
June 2004 Gap Analysis was completed.
November 2004 The Central Securities Depository (CSD) went live as a Department Of Bank Of Ghana.
March 2007  Central Securities Depository Act 2007 (Act 733) was passed.
November 2008  The Ghana Stock Exchange  established a GSE Securities Depository Ltd (GSD), a second Depository to handle equities.
 June 2010  The CSD was incorporated under the name of Central Securities Depository (GH) Limited, a wholly owned subsidiary of Bank Of Ghana.
September 2010 The Board of Directors was inaugurated. 
April 2011 The CSD joined the African and Middle East Depository Association (AMEDA). 
April 2011 The CSD relocated to the British Council wing of the fourth floor of the Cedi House Building.
December 2012 The CSD was "A" rated by Thomas Murray an International Rating Agency. 
September 2013  The CSD was awarded an ISO 27001 Certificate by International Standardization Organization for its Information Security Management.
September 2013  GSD sets upa registrar unit.
October 2013 The CSD completed and implemented successfully its Straight Through Processing (STP) project. 
December 2013 A merger agreement  was signed between The Bank of Ghana and Ghana Stock Exchange for the merger of Central Securities Depository (CSD) and Ghana Stock Exchange Depository (GSD). Bank of  Ghana owns 70% of the new Company with GSE having 30%.
2013 A five year strategic plan was developed by the Depository for the period of 2014-2019.
January 2014  The merger of the CSD and GSD took effect with the Central Securities Depository as the surviving institution from January 1, 2014.
February 2015 The CSD joined the International Securities Services Association (ISSA). On 19th February, 2015, a contract was awarded to Millennium IT, a member of the London Stock Exchange Group to upgrade  the CSD system to version 7 of the MCSD system of the MIT including the migration of both debt and equity securities onto the new CSD system with the Automated Trading System (ATS) and Real Time Gross Settlement (RTGS) system of Bank of Ghana.
March 2016 Securities and Exchange Commission approved the Guidelines developed by CSD for the establishment of the Settlement Guarantee Fund and the Clearing and Settlement Rule developed by CSD.
March 2016 CSD went live with its newly upgraded system on 29th March, 2016 which is capable of handling both fixed income and equity securities. In addition, the new MCSD system was successfully integrated with the ATS of the GSE. Effective 29th March, 2016. CSD took over the activities of the GSE Clearing House.
April 2016 CSD took over the settlement of equity trades from the Clearing House of the Ghana Stock Exchange. All securities transactions settle through Central Bank.
2016 CSD established a settlement Guarantee Fund for both debt and equity markets.
June 2016 Ghana Fixed Income Market (GFIM) was launched to utilise Bloomberg to trade bonds.
October 2016 CSD successfully admitted the maiden 2 Year domestic dollar denominated government securities into the Depository System.